Extra guidance and checking could possibly be important when prescribing for patients liable to opioid misuse.Monitor Closely (1)mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Mitotane is a solid inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates fo